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The prior article on this series presented the standard treatments for opiates addiction. Suboxone allows a new approach.

Using two separate drugs to shed weight can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with weight-loss and the people who go through it you need to err on the side of caution and allow the FDA do its job and demand some investigation be done so that the public is aware of the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies come in business to make money and that they would say almost anything to keep people on the medications.

Researchers discovered that participants investing in this drug for any year, lost excess weight within a month and have kept the load off throughout the 56 weeks with the study. Contrave can be a combination in the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs which are made up of several active ingredient, which can make them more efficient and safer.

Combo-pilling is the newest fad or better yet the newest to come under scrutiny and for that reason it is just more publicly known recently, comb-pilling for weight loss has been around since the eighties. The biggest reason that using a combination of pills has become popular could be the fact that since right now there are no long term prescription weight loss supplements that have been licensed by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications and some of the combinations happen to be rejected or have yet to be approved by the FDA.

Seizures can be a side effect with Contrave and mustn't be taken in people with seizure disorders. The drug can also raise blood pressure and pulse rate, and must not be used in people with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure and heartrate and must 't be used in patients with uncontrolled high blood pressure, in addition to by you are not heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients which has a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes having a boxed warning to alert medical researchers and patients on the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for quitting smoking.


Suboxone is made up of two drugs; buprenorphine and naloxone. The naloxone is irrelevant when the addict uses the medication properly, but when the tablet is dissolved in water and injected the naloxone will cause instant withdrawal. When suboxone is utilized correctly, the naloxone is destroyed in the liver after that uptake through the intestines and has no therapeutic effect. Buprenorphine will be the active substance; it is absorbed within the tongue (and during the entire mouth) but destroyed from the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I have used this formulation once the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I in addition have treated addicts who've had gastric bypass, where the first part of the intestine is bypassed along with the stomach contents empty into a more distal section of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the task with normal anatomy in which the drug is taken up by the duodenum and transferred straight to the liver by the portal vein, where it is quickly and completely destroyed. After gastric bypass naloxone can be taken up by areas of the intestine which are not served through the portal system, causing blood levels of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.
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